Titlebook: Nucleic Acids and Molecular Biology; Fritz Eckstein,David M. J. Lilley Book 1989 Springer-Verlag Berlin Heidelberg 1989 DNA.RNA.biology.en

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Structural Studies of DNA Through Cleavage by the Hydroxyl Radical,he traditional methods for chemical structure determination (for example, X-ray crystallography and NMR), while able to provide important insights into the structures of small DNA oligonucleotides, are at a loss when structural information is needed on much larger natural DNA molecules.

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Resolution of Model Holliday Junctions in Vitro,roken and reformed when the junction moves along the DNA, early investigators proposed that branch migration required little energy and was driven by random diffusion. However, studies of the RecA protein of . have revealed that the process may be more equivalent to a unidirectional walk in which br