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Titlebook: Nucleic Acid Switches and Sensors; Scott K. Silverman Book 2006 Springer-Verlag US 2006 DNA.Nucleotide.RNA.enzymes.proteins

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書目名稱Nucleic Acid Switches and Sensors
編輯Scott K. Silverman
視頻videohttp://file.papertrans.cn/669/668780/668780.mp4
概述The studies described in Nucleic Acid Switches and Sensors demonstrate that interesting and useful molecular-scale switches and sensors can be made out of nucleic acids, by both artificial and natural
圖書封面Titlebook: Nucleic Acid Switches and Sensors;  Scott K. Silverman Book 2006 Springer-Verlag US 2006 DNA.Nucleotide.RNA.enzymes.proteins
描述.In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed. .
出版日期Book 2006
關(guān)鍵詞DNA; Nucleotide; RNA; enzymes; proteins
版次1
doihttps://doi.org/10.1007/978-0-387-47257-7
isbn_softcover978-1-4419-4248-7
isbn_ebook978-0-387-47257-7
copyrightSpringer-Verlag US 2006
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Ribozymes Switched by Proteinsas in the case of natural RNP ribozymes like RNase P that consist of an RNA subunit and an RNA-binding protein. Recent studies have shown that both natural and artificial catalytic RNAs are convertible to allosterically regulated ribozymes by molecular design at the secondary structure or three-dime
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Fluorescence-Signaling Nucleic Acid-Based Sensorss. The simplicity and sequence-specificity of duplex structure formation, the high chemical stability of a duplex, and the convenience of automated synthesis have made DNA oligonucleotides an ideal choice as probes for the detection of nucleic acids. Recently developed in vitro selection techniques
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Protein-Induced RNA Switches in Natureing the grounds for great regulatory potential. RNA function can be turned on or off in very short time scales merely through, for example, the binding of ligands. Conformational switching of RNA molecules can be induced by diverse signals, ranging from large molecules like proteins and RNAs to smal
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is on geomorphology and coastal geology.Continually being u.Springer is pleased to announce .The World‘s Coasts: Online. (TWCO), edited by Eric Bird - an online-only encyclopedia which bases its content on the World‘s Coastline hardbound book content (Van Nostrand Reinhold, 1985) and expands this g
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is on geomorphology and coastal geology.Continually being u.Springer is pleased to announce .The World‘s Coasts: Online. (TWCO), edited by Eric Bird - an online-only encyclopedia which bases its content on the World‘s Coastline hardbound book content (Van Nostrand Reinhold, 1985) and expands this g
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