| 書目名稱 | Nuclear Receptors: From Structure to the Clinic | | 編輯 | Iain J. McEwan,Raj Kumar | | 視頻video | http://file.papertrans.cn/669/668681/668681.mp4 | | 概述 | This book provides state-of-the-art reviews from key researchers in the field.Emphasizes how protein structure is informing a fuller understanding of receptor activity.Provides a comprehensive overvie | | 圖書封面 |  | | 描述 | .Nuclear Receptors. focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity..The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading t | | 出版日期 | Book 2015 | | 關鍵詞 | NMR spectroscopy; glucocorticoids; ligands; nuclear receptors; protein interactions; selective androgen r | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-18729-7 | | isbn_softcover | 978-3-319-37128-3 | | isbn_ebook | 978-3-319-18729-7 | | copyright | Springer International Publishing Switzerland 2015 |
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