Titlebook: Nuclear Receptors; Current Concepts and Chris M. Bunce,Moray J. Campbell Book 2010 Springer Science+Business Media B.V. 2010 ATP.Metazoa.Vi

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The Vitamin D Receptor (NR1I1), on the cellular machinery to absorb calcium in the gut, to re-absorb it in the kidneys and deposit it in the bones. Consequently, insufficiency of the VDR ligand 1α,25dihydroxyvitaminD. (1α25(OH).D.) in a child leads to the classic symptoms of rickets.

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Fxr,itional functions of FXR are identified in enteroprotection, liver regeneration, cancer and aging. These exciting findings suggest that FXR has a broader role than previously thought, and also highlight potential opportunities for using FXR as a drug target for different diseases.

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Ligand Regulation and Nuclear Receptor Action,se or decrease the local concentration of nuclear receptor ligands. The following chapter describes examples of these pathways for regulation of nuclear receptor ligands and their developing importance as therapeutic targets for human disease.

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The Glucocorticoid Receptor,gene regulatory profiles. Here, we discuss the molecular and cellular mechanisms of GR signaling, and the potential role for GR isoforms in regulating the specificity and sensitivity of glucocorticoid responsiveness in healthy and diseased tissues.

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Androgen Receptor,of androgens in many of these conditions. With the rapidly increasing knowledge of AR protein structure and molecular mechanism of action in the last few decades, a large variety of nonsteroidal ligands, have been developed to selectively modulate AR action with much improved tissue and/or function

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