Titlebook: Nuclear Pore Complexes in Genome Organization, Function and Maintenance; Maximiliano D’Angelo Book 2018 Springer International Publishing

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Nuclear Pore Complexes: Fascinating Nucleocytoplasmic Checkpoints,ntrol all bidirectional transport between the cytosol and the nucleus in a highly selective manner thereby turning the nuclear envelope into a selective barrier. NPCs limit passive diffusion to an upper cut-off of ~ 40 kDa but enable selective transport of macromolecules as large as ribonucleoprotei

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Nuclear Pore and Genome Organization and Gene Expression in ,,he Nuclear Pore Complex (NPC) forms the nuclear envelope-spanning channel that mediates selective nucleo-cytoplasmic transport of macromolecules. In addition to contributing to gene expression via its transport functions, the NPC comes in close contact with the underlying chromatin and plays a role

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, Nuclear Pore Complexes in Genome Organization and Gene Expression,s (nucleoporins or nups) are conserved among all eukaryotes, suggesting they evolved in an ancient common ancestor. In addition to their role in nucleocytoplasmic transport, nups located either at NPCs or in the nucleoplasm participate in regulation of gene expression, DNA repair and chromosome segr

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Nuclear Pore Complexes in the Organization and Regulation of the Mammalian Genome,ulation. Nuclear pore complexes (NPCs), the channels that penetrate the NE connecting the nucleus to the cytoplasm, are the largest protein complexes of the NE. Built by multiple copies of roughly 30 different proteins, NPCs were traditionally studied for their role in controlling nucleocytoplasmic

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Nuclear Pore Complexes, Genome Organization and HIV-1 Infection,plasmic transport, and contribute to genome organization, genome stability and gene expression regulation. Some of these cellular functions orchestrated by NPCs are usurped by viruses that replicate in the nucleus. Non-mitotic cells are one of the major targets of HIV-1, thus the passage of the viru

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