Titlebook: Nuclear Imaging in Drug Discovery, Development, and Approval; H. Donald Burns,Raymond E. Gibson,Peter K. S. Sieg Book 1993 Birkh?user Bost

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Conjuction

Nuclear Medicine Physics, Instrumentation, and Data Processing in Pharmaceutical Research,ined from such studies, an appreciation of basic nuclear medicine physics, instrumentation, and data processing is required. The techniques to be considered here include both planar and tomographic imaging, the latter including both Single Photon Emission Computed Tomography (SPECT) and Positron Emi

agenda

Accelerators for Positron Emission Tomography,rement is for these accelerators to deliver particle beams of sufficient energy to bring about the required nuclear reactions and with sufficient beam current to bring about practical yields of the required radionuclides. Table 1 lists the positron emitters, their characteristics and the most common

憤怒事實

Chemistry of Tracers for Positron Emission Tomography,mited number, a select few have been used to study biochemistry and pharmacology . with emission tomography. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) offer biomedical researchers unique opportunities for studying a wide variety of biochemical and phar

Watemelon

Single Photon, Gamma Emitting Radiotracers for Use in Imaging,isotopically labeled compounds (primarily Carbon-11 or Fluorine-18) and Positron Emission Tomography (PET) imaging to obtain information on drug absorption, distribution, metabolism and elimination. Imaging studies in humans with these labeled drugs or drug candidates can be used to compliment infor

incite

LAVA

Applications of Autoradiography to Drug Discovery,atures which define the usefulness of Nuclear Medicine in drug discovery are applicable to autoradiographic techniques. Additionally, autoradiographic studies, both . and ., have been used to characterize the properties of radiolabeled drugs used in nuclear medicine (Huang and Phelps, 1986; Kung et

本土

membrane

uncertain

Positron Emission Tomography, Enzymes and Drug Research and Development,havioral, therapeutic and toxic properties of drugs is emerging as a powerful new scientific tool (Fowler et al., 1990). PET provides a new perspective on drug research by virtue of its ability to directly assess different parameters such as absolute uptake, regional distribution, kinetics, pharmaco