Titlebook: Nuclear G-Protein Coupled Receptors; Methods and Protocol Bruce G. Allen,Terence E. Hébert Book 2015 Springer Science+Business Media New Yo

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Design and Application of Light-Activated Probes for Cellular Signaling, where they are able to modulate nuclear Ca. influx, transcription initiation, and gene expression. Because GPCRs represent “some of the most promising targets for drug development” a better understanding of their roles, not only at the cell membrane but also at the nuclear level, in healthy and dis

ACE-inhibitor

Using Caged Ligands to Study Intracrine Endothelin Signaling in Intact Cardiac Myocytes,mbrane. The presence and function of nuclear receptors have been studied in isolated nuclei. Much less information is available concerning the function of these receptors within the context of intact cells due, in part, to difficulties in accessing the intracellular receptor without activating those

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Quantification of Catecholamine Uptake in Adult Cardiac Myocytes,giotensin type 1 and 2 receptors, β1- and β3-adrenergic receptors, and α1A- and α1B-adrenergic receptors. Initiation of signaling through nuclear GPCRs requires that ligands be produced within or transported into the cardiac myocytes, yet mechanisms whereby these ligands are produced or transported

lipoatrophy

Characterization of the Interaction Between the Prostaglandin D, DP1 Receptor and the Intracellularrization of identified interactions can be difficult with GPCRs, especially at the endogenous level. Here, we describe how we characterized the interaction between the prostaglandin D. DP1 receptor and the intracellular .-type prostaglandin D synthase by in vitro pull-down assays using purified reco

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Isolation and Study of Cardiac Nuclei from Canine Myocardium and Adult Ventricular Myocytes,he maturation of nascent RNA. Recent studies ascribe a growing number of functions to the nuclear membrane, in addition to sequestering the DNA, through receptors and their effectors, ion channels, as well as ion pumps and transporters located within the nuclear membrane itself. Despite the obvious

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