Titlebook: Novel Therapeutics from Modern Biotechnology; From Laboratory to H Dale L. Oxender,Leonard E. Post (Vice President, D Book 1999 Springer-Ve

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Preparation of Clinical Trial Supplies of Biopharmaceuticals,le time is available to optimize product gene expression or cell growth. Systems that are often employed include: 1) suspension culture in spinner vessels, roller bottles or other containers, 2) ascites production in mice, and 3) hollow-fiber bioreactors.

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Novel Therapeutics from Modern Biotechnology978-3-642-59990-3Series ISSN 0171-2004 Series E-ISSN 1865-0325

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Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/n/image/668468.jpg

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Preparation of Clinical Trial Supplies of Biopharmaceuticals,le time is available to optimize product gene expression or cell growth. Systems that are often employed include: 1) suspension culture in spinner vessels, roller bottles or other containers, 2) ascites production in mice, and 3) hollow-fiber bioreactors.

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Proteins as Drugs: Analysis, Formulation and Delivery,ever, the advent of recombinant DNA technology has resulted in a dramatic expansion of interest in their pharmaceutical applications. It now appears that we can make virtually any desired protein in sufficient quantities for therapeutic use, although often with significant difficulty. It is consider

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Strategies for Dealing With the Immunogenicity of Therapeutic Proteins,at their potential for use as therapeutics would be extremely high. However, the recognizable need for a defense system has implications for the administration of protein-based pharmaceuticals (Table 1). Minor differences in the primary structure of proteins—even as little as one amino acid from the

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