Titlebook: Novel Inhibitors of Leukotrienes; Giancarlo Folco,Bengt Samuelsson,Robert C. Murphy Book 1999 Springer Basel AG 1999 asthma.cell.developme

Protein

Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation, by LTC. synthase, to produce 5(.)-hydroxy-6(.)-.-glutathionyl-7,9-.-11,14-.-. acid (LTC.). This review will focus on the biochemistry and molecular biology of LTA. hydrolase, the enzyme catalyzing the final step in the biosynthesis of the potent chemotaxin LTB., an important mediator of inflammation.

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Prophylaxis

LTB4 receptor antagonists,ribe studies on the more interesting compounds that have been synthesized with particular emphasis on those that have entered clinical trial and then address some issues of concern to investigators working in this area.

squander

遭遇

Fulsome

Entry rate and metabolic handling of LTC4 in the human circulation,se in patients with asthma and other disease states characterized by an inflammatory component. In this regard, urinary LTE. excretion rates have been extensively used over the last 5 years, following demonstration that the intravenous infusion [1–3] or inhalation [4] of LTC. is accompanied by dose-dependent increments in LTE. excretion.

骨

Leukotrienes and aspirin-intolerant asthma,his is a distinct clinical syndrome, called aspirin-induced asthma, or aspirin-intolerant asthma (AIA). It affects about 10% of adult patients with asthma, more often women than men, but is rare in asthmatic children [1–3].

PANIC

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鋼盔

Novel Inhibitors of Leukotrienes978-3-0348-8703-8Series ISSN 1422-7746 Series E-ISSN 2296-4525