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Titlebook: Novel Developments in Stem Cell Mobilization; Focus on CXCR4 Stefan Fruehauf,W. Jens Zeller,Gary Calandra Book 2012 Springer Science+Busine

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發(fā)表于 2025-3-21 18:09:23 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Novel Developments in Stem Cell Mobilization
副標題Focus on CXCR4
編輯Stefan Fruehauf,W. Jens Zeller,Gary Calandra
視頻videohttp://file.papertrans.cn/669/668384/668384.mp4
概述A concise review of the current status of knowledge and future developments of CXCR4 will be presented.Contributors are internationally leaders in the field.A comprehensive treatment of the subject wi
圖書封面Titlebook: Novel Developments in Stem Cell Mobilization; Focus on CXCR4 Stefan Fruehauf,W. Jens Zeller,Gary Calandra Book 2012 Springer Science+Busine
描述Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.
出版日期Book 2012
關鍵詞CXCR4; Cancer Research; Mobilization; Plerixafor; Stem Cell
版次1
doihttps://doi.org/10.1007/978-1-4614-1960-0
isbn_softcover978-1-4899-9376-2
isbn_ebook978-1-4614-1960-0
copyrightSpringer Science+Business Media, LLC 2012
The information of publication is updating

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