| 書目名稱 | Novel Anticancer Drug Protocols | | 編輯 | John K. Buolamwini,Alex A. Adjei | | 視頻video | http://file.papertrans.cn/669/668341/668341.mp4 | | 概述 | Includes supplementary material: | | 叢書名稱 | Methods in Molecular Medicine | | 圖書封面 |  | | 描述 | We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin? (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia. | | 出版日期 | Book 2003 | | 版次 | 1 | | doi | https://doi.org/10.1385/1592593801 | | isbn_softcover | 978-1-4899-3839-8 | | isbn_ebook | 978-1-59259-380-4Series ISSN 1543-1894 Series E-ISSN 1940-6037 | | issn_series | 1543-1894 | | copyright | Springer Science+Business Media New York 2003 |
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