Titlebook: Notch Regulation of the Immune System; Freddy Radtke Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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asics and - cent, more sophisticated, theoretical developments in panel data econometrics. It also aims at covering a number of ?elds of applications where these methods are used for improving our knowledge and understanding of economic agents’ beh- iors. Since the pioneering works of Edwin Kuh (195

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Notch Receptor-Ligand Interactions During T Cell Development, a Ligand Endocytosis-Driven Mechanisment, in particular in the development and commitment to the T cell lineage, has been the focus of research for many years. Notch signaling is absolutely required during the commitment and early stages of T cell development. Activation of the Notch signaling pathway is initiated by ligand-receptor in

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Notch1 and IL-7 Receptor Signalling in Early T-cell Development and Leukaemia,ication of bone marrow-derived multipotent progenitors that seed the thymus, and for proliferation and further progression of early thymocytes along the T-cell lineage. Deregulated activation of Notch1 significantly contributes to the generation of T-cell acute lymphoblastic leukaemia (T-ALL). In ad

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Canonical and Non-Canonical Notch Signaling in CD4+ T Cells, cell surface receptors are transduced and amplified through a coordinated circuitry of signaling cascades that ultimately result in the transcription of new genes. Along the way, extracellular and intracellular signaling components function to impart a fully activated state. Evidence is accumulatin

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The Role of Notch in the Differentiation of CD4+ T Helper Cells,igen-specific recognition, receive signals to differentiate into distinct effector T helper cell subsets characterized by their pattern of cytokine production and specific immune functions. A tight balance between these different subsets ensures proper control of the immune response. There is increa

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