Titlebook: Non-Viral Gene Delivery Vectors; Methods and Protocol Gabriele Candiani Book 2016 Springer Science+Business Media New York 2016 conventiona

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Polymer Based Gene Silencing: In Vitro Delivery of SiRNARNA is dependent on its delivery to the intracellular space. This chapter describes the delivery of siRNA by .-(2-ethylamino)-6-.-glycolchitosan (EAGC). EAGC is a chitosan-based polymer, which binds to siRNA to form nanoparticles (NPs). The steps necessary to determine the delivery capacity of a pol

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Polyallylamine Derivatives: Novel NonToxic Transfection Agentse in the context of using cationic polymers as carriers is the balance between the high transfection efficiency and low cytotoxicity. In this chapter, we report the preparation of polyallylamine derivatives mainly based on substitution of amino groups by glycidyltrimethylammonium chloride. The resul

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Biodegradable Three-Layered Micelles and Injectable Hydrogelscationic polymer polyethylene imine (PEI) has shown relatively high condensation and transfection efficiencies. Additionally, polyethylene glycol (PEG) modification of polymeric gene vectors has dramatically improved their biological properties, including enhanced biocompatibility, prolonged circula

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