Titlebook: Non-Neoplastic Liver Pathology; A Pathologist’s Surv Raul S. Gonzalez,Kay Washington Book 2016 Springer International Publishing Switzerlan

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Cholestasis,e biliary tree, from hepatocellular canaliculi to small or large bile ducts. In many instances, cholestasis is a relatively minor component of the pathologic changes seen in a specimen, but in other cases, it may be the only pathologic change (this is known as “bland cholestasis”). Cholestasis may r

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Granulomas,eating), necrotic palisading granulomas (i.e., abscessed or suppurative granulomas), lipogranulomas, foamy macrophage aggregates, microgranulomas, and fibrin ring granulomas. A condensed differential diagnosis is available in Table 9.1.

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Sinusoidal Changes,aping spaces between the hepatocyte plates catch the eye (Fig. 10.1). The sinusoids may be empty or may be filled with inflammatory cells or foreign material. In rare cases, the sinusoidal changes serve as evidence of malignancy.

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Necrosis,d, confluent necrosis, destroying a large number of cells at once. This manifests as large swaths of dead lobular parenchyma, sometimes following zonal patterns and sometimes spreading haphazardly (Fig. 11.1).

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Steatosis,Steatosis (fatty change) is a relatively common finding in liver specimens. A small amount (no more than about 5?%) is not considered pathologic, but larger amounts are often attributable to a disease state. In most circumstances, the steatosis collects in a zonal fashion, starting in zone 3 and working its way into the rest of the lobule.

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Fibrosis and Cirrhosis,This brief chapter will discuss usual and unusual patterns of fibrosis, along with approaches to cirrhosis in a patient without a known history of liver disease. Cirrhosis in the pediatric population is discussed in Chap. 15.