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Titlebook: Next Generation Sequencing Technologies and Challenges in Sequence Assembly; Sara El-Metwally,Osama M. Ouda,Mohamed Helmy Book 2014 The Au

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書目名稱Next Generation Sequencing Technologies and Challenges in Sequence Assembly
編輯Sara El-Metwally,Osama M. Ouda,Mohamed Helmy
視頻videohttp://file.papertrans.cn/667/666225/666225.mp4
概述Focuses on challenges in next generation sequencing technologies.Challenges include sequencing errors, expensive processing and memory usage and sequencer specific errors.This book provides overview o
叢書名稱SpringerBriefs in Systems Biology
圖書封面Titlebook: Next Generation Sequencing Technologies and Challenges in Sequence Assembly;  Sara El-Metwally,Osama M. Ouda,Mohamed Helmy Book 2014 The Au
描述.The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field..This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges..
出版日期Book 2014
關(guān)鍵詞challenges; genomics; next generation sequence technologies; next generation sequencing; sequence assemb
版次1
doihttps://doi.org/10.1007/978-1-4939-0715-1
isbn_softcover978-1-4939-0714-4
isbn_ebook978-1-4939-0715-1Series ISSN 2193-4746 Series E-ISSN 2193-4754
issn_series 2193-4746
copyrightThe Authors 2014
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Basics of Molecular Biology for Next-Generation Sequencingdequate introduction to the subject. These basics would greatly aid a lay audience in understanding this and other computational biology resources and textbooks. Readers with a firm biological background may choose to skip this chapter.
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Challenges in the Next-Generation Sequencing Fieldst few years. We have previously described how next-generation sequencing has advanced DNA sequencing from low throughput to high throughput and minimized labor-intensive practices to more automated processes. In this chapter, we will compare next-generation sequencing with the traditional Sanger me
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