Titlebook: New Psychoactive Substances; Pharmacology, Clinic Hans H. Maurer,Simon D. Brandt Book 2018 Springer Nature Switzerland AG 2018 New psychoac

Exposition

Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances,5-HT and NE release. Monoamine receptor interactions vary considerably among amphetamine- and MDMA-like NPS. Clinically, amphetamine- and MDMA-like NPS can induce sympathomimetic toxicity. The aim of this chapter is to review the state of knowledge regarding these substances with a focus on the desc

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The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists as New Psychoactive Substcture and function of the primary target for SCRAs, the CB. receptor, and survey the structure-activity relationships of the historical SCRAs that served as templates for the earliest generations of NPS.

好色

The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substancegand bias, metabolism, or off-target activity. This chapter will chart the evolution of recently identified SCRA NPS chemotypes, as well as their putative manufacturing by-products and thermolytic degradants, and describe structure-activity relationships within each class.

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Dawdle

Phencyclidine-Based New Psychoactive Substances,ed represented compounds already known in the scientific literature. As the decade of the noughties unfolded, a number of new PCP-derived substances appeared on the scene, which included some analogs that have not been previously recorded in the published literature. The aim of this chapter is to pr

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1,2-Diarylethylamine- and Ketamine-Based New Psychoactive Substances,eously with ease through the Internet. Some individuals used this newly found opportunity to discuss the chemistry and psychoactive effects of dissociative drugs as well as to collaborate on the design and development of novel dissociative compounds. Similar to modern pharmaceutical companies and ac

MELD

Synthetic Opioids, depression induced by these newer synthetic opioids to be especially refractive to reversal by antagonists, with consequently high levels of lethality. This review examines three of these synthetic opioids representing three chemical classes (U-47700, MT-45, and acetylfentanyl) that have emerged to

Aura231

Designer Benzodiazepines: Another Class of New Psychoactive Substances, used 1,4-benzodiazepines based on structure-activity relationships as well as synthesis of active metabolites and triazolo analogs of these compounds. As they were obviously designed to circumvent national narcotics laws or international control, they can be referred to as “designer benzodiazepines

Loathe

Toxicokinetics of NPS: Update 2017,low for detection of NPS in biological matrices in cases of acute intoxications or chronic consumption. Although some data are available, scientific papers dealing with the mechanistic reasons behind acute and chronic toxicity are still lacking.

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