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Titlebook: New Neuromuscular Blocking Agents; Basic and Applied As Dimitry A. Kharkevich (Professor and Chairman of t Book 1986 Springer-Verlag Berlin

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發(fā)表于 2025-3-21 18:56:05 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱New Neuromuscular Blocking Agents
副標(biāo)題Basic and Applied As
編輯Dimitry A. Kharkevich (Professor and Chairman of t
視頻videohttp://file.papertrans.cn/666/665523/665523.mp4
叢書名稱Handbook of Experimental Pharmacology
圖書封面Titlebook: New Neuromuscular Blocking Agents; Basic and Applied As Dimitry A. Kharkevich (Professor and Chairman of t Book 1986 Springer-Verlag Berlin
描述The problems associated with the pharmacologic and physiologic regulation of neuromuscular transmission and of the morphofunctional organization of neuromuscular junctions have attracted a wide range of investigators. Numerous handbooks, monographs, and reviews are devoted to this subject. At the same time, many fundamental and applied aspects of this trend continue to progress succesfully. In recent years, new experimental and clinical data on the structure and function of neuromuscular junctions have been gained, and new, more perfect neuromuscular blocking agents have been designed. It is these data that the present handbook mainly deals with. A considerable number of chapters have been written by authors from eastern Europe. This was done intentionally since much of their work has previously been published only in their own languages, and is thus inaccessible to most Western readers. This is why some of the data included in the volume are not quite the latest, but they contain fruitful ideas or important results and are of value for further progress in the pharmacology of neuromuscular transmission. Naturally, the methodological level of the investigations differs, depending on
出版日期Book 1986
關(guān)鍵詞Acetylcholin; Aldehyde; Histamin; Nicotin; Respiration; antibiotics; metabolism; methylation; mutagenesis; ph
版次1
doihttps://doi.org/10.1007/978-3-642-70682-0
isbn_softcover978-3-642-70684-4
isbn_ebook978-3-642-70682-0Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1986
The information of publication is updating

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On the Principles of Postsynaptic Action of Neuromuscular Blocking Agentsrtainly be argued that the important facts about tubocurarine were all known long before the voltage clamp was invented, it could not be argued that the reasons for its behaviour were understood. The emphasis in this chapter will be on the fundamental molecular effects of the drugs, rather than on t
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On the Comparative Sensitivity of Acetylcholine Receptors of Various Groups of Skeletal Muscles to Nes. Thus, for instance, tubocurarine causes relaxation, first, of the cervical and facial muscles, then, of the muscles of the torso and limbs, and last, of respiratory muscles (intercostal and diaphragm). Often, this is considered to be true of other neuromuscular blocking agents, although the data
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The Interaction of Neuromuscular Blocking Agents With Human Cholinesterases and Their Binding to Plaof the ester type NMBA, e.g., succinylcholine chloride (suxamethonium; SCh), suxethonium bromide, are hydrolyzed by human plasma butyrylcholinesterase (EC 3.1.1.8; BuChE) (. and . 1953; . et al. 1956). Their hydrolysis rate in most other mammalian plasmas is much lower than in human plasma (. and .
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Biodegradation and Elimination of Neuromuscular Blocking Agentsns. Thus, although quaternary ammonium compounds can be degraded to tertiary amines, in general this requires treatment with caustic alkali, i.e. approximately pH 14, at temperatures of around 100 °C (. 1851). It is not surprising, therefore, that the tetraalkylammonium group is not normally subject
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