Titlebook: New Methods for the Study of Biomolecular Complexes; Werner Ens,Kenneth G. Standing,Igor V. Chernushevi Book 1998 Springer Science+Busines

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Approaches to the Characterisation of Tertiary and Supramolecular Protein Structures by Combination etric structure analysis of proteins. Whereas ESI-MS provides direct information about solution structures and non-covalent interactions, the combination of mass spectrometry with structure-specific protein chemistry is emerging presently as a powerful tool for characterising tertiary structures and

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Protein-Ligand Binding Studied by Amide Hydrogen Exchange and Mass Spectrometryve to their access to the aqueous solvent. If ligands shield the binding sites from the solvent, isotopic exchange of hydrogens located in the vicinity of the binding sites might be the basis of a method for locating ligand binding sites on proteins. Although successful applications of this approach

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Investigation of the Effect of Protein Oxidation Upon the Lipid-Binding Activity of the Cerebroside- some brain membrane lipids. Deficiency of the protein leads to a lethal form of metachromatic leukodystrophy due to a disruption in sulfatide metabolism and demyelination. The porcine protein, whose primary structure has been solved [Stevens R.L., Faull K.F., Conklin K.A., Green B.N. and Fluharty A

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The Use of Chemical Ligation for Investigation of the Structure of Duplexes Formed by Linear and Cirycircular compounds (catenanes) are formed during DNA replication and recombination [1, 2]. Here we report investigations of the possibility of using chemical ligation for the study of feasible types of linear oligonucleotide hybridization on linear and circular templates as well as for the design o

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Measurement of Noncovalent Complexes with High m/z by Electrospray Time-of-Flight Mass Spectrometry biomolecules [1]. However, most ES-MS studies with proteins have been carried out in acidic solutions. Such acidic solutions, particularly in combination with organic solvents, denature biopolymers, which then acquire sufficient charge to be detected within the limited ./. range of most commercial

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Observation of Non-Covalent Complexes of Citrate Synthase and NADH by ESI/TOF Mass Spectrometryof the electrospray technique preserves higher order structures, allowing their accurate mass measurement by time-of-flight mass spectrometry over a wide m/z range. Here we demonstrate the application of ESI/TOF MS in the detection of noncovalent complexes and quaternary structural changes as a resu

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