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Titlebook: New Aspects for Treatment with Fosfomycin; Josef-Peter Guggenbichler Book 1987 Springer-Verlag/Wien 1987 absorption.antibiotic.antibiotics

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書目名稱New Aspects for Treatment with Fosfomycin
編輯Josef-Peter Guggenbichler
視頻videohttp://file.papertrans.cn/665/664831/664831.mp4
圖書封面Titlebook: New Aspects for Treatment with Fosfomycin;  Josef-Peter Guggenbichler Book 1987 Springer-Verlag/Wien 1987 absorption.antibiotic.antibiotics
描述Fosfomycin is an antimicrobial substance which is available since several years. In earlier clinical studies an oral preparation with poor absorption in a low dosage resulted in inadequate therapeutic results. The presently used parenteral administration in a dosage range of up to 250 mg/kg BW however allowed us to appreciate several unique properties of this drug which make it valuable in the treatment of serious bacterial infections. Due to its small molecular weight and complete lack of protein binding a favorable penetration in tissues and deep compartments (e.g., meninges, bone, heart valves) was observed. In addition fosfomycin shows a remarkably low toxicity and even protects from the nephrotoxigenic effects of aminoglycosides and other drugs. Earlier problems in antimicrobial susceptibility testing have been solved by addition of glucose 6 phosphate into the growth medium. Fosfomycin, the first representative of a completely new class of antibiotics does not show cross-resistance with other antibiotics; therefore pathogens of nosocomial infections, particularly methicillin- und gentamicin-resistant staphylococci are mostly susceptible to this antibiotic. Clinical investigat
出版日期Book 1987
關(guān)鍵詞absorption; antibiotic; antibiotics; drug; infection; meningitis; muscle; oncology; research; resistance; surg
版次1
doihttps://doi.org/10.1007/978-3-7091-8903-0
isbn_softcover978-3-211-81986-9
isbn_ebook978-3-7091-8903-0
copyrightSpringer-Verlag/Wien 1987
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