Titlebook: Neutralization of Animal Viruses; Nigel J. Dimmock Book 1993 The Editor(s) (if applicable) and The Author(s), under exclusive license to S

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Properties of Protein and Peptide Antigens Which Elicit Neutralizing Antibody, example of lysozyme, 16 amino acid residues of the epitope are involved in interaction with 17 of the paratope (. et al. 1986). The conventional view of the antibody binding site being a cleft capable of accomodating about six amino acid residues does not explain the simultaneous binding of two dif

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Neutralization In Vivo, easy to determine how such antibody acts. However, immunoglobulin-mediated immunity is easily demonstrated by adoptive transfer to naive animals. In this way it was shown that some monoclonal IgGs which neutralize in vitro confer protection in vivo and others do not; the latter include antibodies t

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Complement and Neutralization,ment of virus-antibody complexes to complement receptors on cells (see Sect. 8); it can enhance neutralization or bring about loss of infectivity with non-neutralizing antibody or sub-neutralizing amounts of neutralizing antibody; and it can bring about the solubilization of antigen-antibody aggrega

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