| 書目名稱 | Neuroproteomics | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Andrew K. Ottens,Kevin K.W. Wang | | 視頻video | http://file.papertrans.cn/665/664382/664382.mp4 | | 概述 | Presents a modular approach to experimental design, covering neurodegenerative models, subproteome selection technologies, quantitative and qualitative mass spectrometry, data analysis and clinical tr | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | Neuroproteomics: Methods and Protocols presents experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. The target audience includes clinical or basic scientists who look to apply proteomics to the neurosciences. Often researchers hear of proteomics without an adequate explanation of the methodology and inherent limitations. This volume conveys where proteomic methodology is in its application to CNS research and what results can be expected. We also address clinical translation of neuroproteomics, specifically in the area of biomarker research. The inception of neuroproteomics capitalized on rapid progress in large-molecule mass spectrometry over the last decade. Two seminal advances have spurred research – development of reliable polypeptide ionization processes and bioinformatics to rapidly process tandem mass spectra for peptide identification and quantification. What has followed is the exponential application of mass spectrometry to proteome characteri- tion across biological and biomedical disciplines. Arguably, the most elaborate proteomic implementation is in studying the CNS, the most en | | 出版日期 | Book 2009 | | 關(guān)鍵詞 | Biofluid analysis; Bioinformatics; Biomarker research; Central nervous system - CNS; Clinical translatio | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-562-6 | | isbn_softcover | 978-1-61779-754-5 | | isbn_ebook | 978-1-59745-562-6Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2009 |
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