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Titlebook: Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP); Caroline Fonta,László Négyessy Book 2015 Springer Science+Business Media Dordrech

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發(fā)表于 2025-3-21 17:03:51 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)
編輯Caroline Fonta,László Négyessy
視頻videohttp://file.papertrans.cn/665/664280/664280.mp4
概述Offers a wealth of new information on alkaline phosphatase TNAP functions in the nervous system.Opens up new insights on the regulation of neural functions.A valuable resource for both researchers and
叢書(shū)名稱Subcellular Biochemistry
圖書(shū)封面Titlebook: Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP); Caroline Fonta,László Négyessy Book 2015 Springer Science+Business Media Dordrech
描述Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer‘s disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.
出版日期Book 2015
關(guān)鍵詞Brain development; Cerebral cortex; Epilepsy; Metabolic disorders; Neurobiology
版次1
doihttps://doi.org/10.1007/978-94-017-7197-9
isbn_softcover978-94-024-0273-5
isbn_ebook978-94-017-7197-9Series ISSN 0306-0225 Series E-ISSN 2542-8810
issn_series 0306-0225
copyrightSpringer Science+Business Media Dordrecht 2015
The information of publication is updating

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The Retinal TNAPwell as diseases of the nervous system. Exploration of TNAP in well characterized neural circuits such as the retina, might significantly advance our understanding regarding neural TNAP’s roles. This chapter reviews the scarce literature as well as our findings on retinal TNAP. We found that retinal
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發(fā)表于 2025-3-22 18:52:06 | 只看該作者
Tissue Non-specific Alkaline Phosphatase (TNAP) in Vessels of the Brainange (20?m.) between the blood and the parenchyma of brain. Under influence of surrounding tissues, the brain microvessel endothelium expresses a specific phenotype that regulates and restricts the entry of compounds and cells from blood to brain, and defined the so-called blood–brain barrier (BBB).
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TNAP, an Essential Player in Membrane Lipid Rafts of Neuronal Cellsand is expressed in different tissues. As the other members of the ecto-phosphatase family, TNAP is targeted to membrane lipid rafts. Such micro domains enriched in particular lipids, are involved in cell sorting, are in close contact with the cellular cytoskeleton and play the role of signaling pla
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發(fā)表于 2025-3-23 05:55:10 | 只看該作者
Signal Transduction Pathways of TNAP: Molecular Network Analysese epilepsy and Alzheimer’s disease, our understanding about the role of TNAP in the regulation of neurotransmission is severely limited. The aim of our study was to integrate the fragmented knowledge into a comprehensive view regarding neuronal functions of TNAP using objective tools. As a model we
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