Titlebook: Neuroimmune Diseases; From Cells to the Li Hiroshi Mitoma,Mario Manto Book 20191st edition Springer Nature Switzerland AG 2019 neuroimmunol

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Neuroimmune Diseases978-3-030-19515-1Series ISSN 2627-535X Series E-ISSN 2627-5341

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Contemporary Clinical Neurosciencehttp://image.papertrans.cn/n/image/664093.jpg

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https://doi.org/10.1007/978-3-030-19515-1neuroimmunology; immunotherapy; autoimmunity; pathogenesis; neuroimmune diseases

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Overview of Mechanisms Underlying Neuroimmune Diseasesy of current research is focused on the genetic association, biomarker discovery, differential diagnosis, treatment choices, and identification of immunological and neurological basis of neuroimmune diseases. In this chapter, we discuss the clinical and pathological features of neuroimmune diseases

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Roles of Effector T Cells in Neurological Autoimmunitynterleukin (IL)-17-expressing Th17 cells are also essential for disease pathogenesis. Furthermore, CD8+ T cells are predominantly observed in human MS lesion sites. However, their functions in this disease are understudied. In this chapter, we summarize the roles of effector T cells in neuroimmune d

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The Role of Th17 Cells in Immunopathogenesis of Neuroinflammatory DisordersFas/FasL interaction. Th17 cells increase migration of other immune cells such as neutrophils into the inflamed CNS through the blood-brain barrier (BBB) and trigger the inflammatory reactions that occasionally lead to irreversible neuronal damages. Therefore, it is not surprising that these cells a

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The Roles of Regulatory T Cells in Central Nervous System AutoimmunityCNS, including multiple sclerosis, neuromyelitis optica, acute disseminated encephalomyelitis, anti-NMDAR encephalitis, and narcolepsy with cataplexy. Although the role of Treg cells in some of these conditions is still very much in the preliminary stages, it is a feasible notion that with more rese

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Autoimmune Astrocytopathyiated with tumors. Similarly, in Rasmussen’s encephalitis, CD8. T lymphocytes cause astrocyte apoptosis and loss in affected areas, altering normal neuron function. Reactive astrocytes also play an important role in different CNS infections, not only during acute phases of disease but also long term