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Titlebook: Neurodegenerative Disorders: Loss of Function Through Gain of Function; Konrad Beyreuther,Yves Christen,Colin L. Masters Conference procee

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發(fā)表于 2025-3-21 20:09:22 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Neurodegenerative Disorders: Loss of Function Through Gain of Function
編輯Konrad Beyreuther,Yves Christen,Colin L. Masters
視頻videohttp://file.papertrans.cn/664/663985/663985.mp4
叢書名稱Research and Perspectives in Alzheimer‘s Disease
圖書封面Titlebook: Neurodegenerative Disorders: Loss of Function Through Gain of Function;  Konrad Beyreuther,Yves Christen,Colin L. Masters Conference procee
描述A fundamental change is occurring in the understanding of the major neurodegenerative disorders. Protein aggregation is a common emerging theme in diseases as diverse as Alzheimer‘s, Creutzfeld-Jakob, Parkinson‘s, and amyotrophic lateral sclerosis. If valid, then a small number of diagnostic and rational therapeutic strategies will emerge over the next few years, based on the common theme of modulation of the production, turnover and deposition of these aggregating proteins. The book provides insights into the cellular and animal models of these diseases, and how the molecular basis of neurodegeneration has become the preferred target of therapy.
出版日期Conference proceedings 2001
關(guān)鍵詞Alzheimer; Alzheimer‘s Disease; Huntingdon‘s Disease; amyloid precursor protein; amyotrophic lateral scl
版次1
doihttps://doi.org/10.1007/978-3-662-04399-8
isbn_softcover978-3-642-07448-6
isbn_ebook978-3-662-04399-8Series ISSN 0945-6066 Series E-ISSN 2196-310X
issn_series 0945-6066
copyrightSpringer-Verlag Berlin Heidelberg 2001
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發(fā)表于 2025-3-21 23:39:27 | 只看該作者
https://doi.org/10.1007/978-3-662-04399-8Alzheimer; Alzheimer‘s Disease; Huntingdon‘s Disease; amyloid precursor protein; amyotrophic lateral scl
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發(fā)表于 2025-3-22 01:30:08 | 只看該作者
978-3-642-07448-6Springer-Verlag Berlin Heidelberg 2001
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發(fā)表于 2025-3-22 05:47:24 | 只看該作者
Neurodegenerative Disorders: Loss of Function Through Gain of Function978-3-662-04399-8Series ISSN 0945-6066 Series E-ISSN 2196-310X
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Mechanisms of Motor Neuron Death in ALS,e most common form of adult motor neuron disease in humans, ALS typically initiates in middle to late life, leading to paralysis and death within three to five years. The disease usually begins asymmetrically in one limb, most commonly the leg, and then appears to spread to involve contiguous groups
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The Value of Transgenic Models for the Study of Neurodegenerative Diseases,d, chronic illnesses that are among the most challenging and devastating diseases in medicine (Becker et al. 1998; Burright et al. 1995; Cleveland 1999; Davies et al. 1997; Goedert et al. 1998; Hardy and Gwinn-Hardy 1998; Lin et al. 1999; Mangiarini et al. 1996; Price et al. 1998b; Robitaille et al.
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Pathogenesis and Mechanism of Cerebral Amyloidosis in APP Transgenic Mice,ellular deposition of amyloid in plaques and vessels. In an effort to study the impact of cerebral amyloidosis on neurodegeneration, we have shown that amyloid plaque formation in APP transgenic mice is accompanied by region-specific neuron loss, synaptic changes, alterations in the cholinergic syst
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