Titlebook: Neurodegenerative Diseases; Molecular and Cellul Gary Fiskum Book 1996 Springer Science+Business Media New York 1996 Alzheimer.Amino acid.C

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Biology of APP and its Homologues APLPs in the mammalian nervous system are far from clear, although several studies have suggested that APP play roles in cell-cell or cell-matrix interactions,. calcium hemostasis,. growth promoting activities,. and the formation/maintenance of synapses .. More recently, investigations in cultured

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The Non-Amyloid-β Component of Alzheimer’s Disease Plaque Amyloid: Comparative Analysis Suggests a Nphosphorylated on serine residues, and have suggested it is also phosphorylated on tyrosine.; they named the protein Phosphoneuroprotein-14-kDa (PNP-14). More recently, Jakes et al.., using an antibody originally raised against paired helical filaments, detected two forms of the same human protein,

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Mutations of Human Cu, Zn Superoxide Dismutase Expressed in Transgenic Mice Cause Motor Neuron Diseaf Superoxide (O.×.) to hydrogen peroxide (H.O.). The copper ion provides the redox center for the dismutation of Superoxide, while the zinc ion plays a structural role. Three different genes encoding Superoxide dismutases are present in the human genome. All three enzymes contain a transition metal

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Davide Trotti,Niels C. Danbolt,Barbara Lodi Rizzini,Paola Bezzi,Daniela Rossi,Giorgio Racagni,Andrea

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Sangram S. Sisodia Ph.D.,Gopal Thinakaran Ph.D.,Cornelia S. von Koch B.A.,Hilda H. Slunt B.S.,A. Jan