Titlebook: Neurodegeneration in Multiple Sclerosis; Massimo Filippi,Marco Rovaris,Giancarlo Comi Book 2007 Springer-Verlag Milan 2007 Alzheimer.Alzhe

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T1 Black Holes and Gray Matter Damageis (MS). MRI has emerged as a key supportive therapeutic outcome measure in MS-related clinical trials. The limitations of conventional MRI surrogates have driven researchers to develop better biomarkers, including those capturing destructive aspects of the disease. In this chapter, we discuss the m

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Introduction

Diffusion-Weighted Imaging than clinical assessment in detecting disease dissemination over space and time [.] and for revealing the occurrence of disease activity and the accumulation of disease burden over time. Nevertheless, the discrepancies between clinical and conventional MRI findings in patients with established MS [

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Functional MRI sclerosis (MS) [.] with the ultimate goal of increasing our understanding of the mechanisms responsible for the accumulation of irreversible disability. The application of these techniques has provided important insights into the pathobiology of MS. First, it has been demonstrated that MS-related d

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Defining Responders and Non-responders from this treatment? In an effort to answer the question, astute clinicians observe patients serially; in other words, they will try a treatment on the patient and then adjust the therapy if his or her condition does not respond. Although the sample size in this experiment is . = 1, the observation

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