Titlebook: Neurobiology; Methods and Protocol Sebastian Dworkin Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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High-Throughput Multiplex Immunohistochemistry of Glioma Organoids,roenvironment. In particular, cancer cells form a reciprocal relationship with noncellular dysregulated extracellular matrix in the tumors. Here, we describe a protocol that can be used to model the functional relationship between tumor cells and extracellular matrix. We demonstrate how 3D organoids

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The Bilateral Carotid Artery Stenosis (BCAS) Model of Vascular Dementia,elopment of vascular dementia. In this chapter, we describe the surgical procedures used for bilateral carotid artery stenosis (BCAS) surgery to induce chronic cerebral hypoperfusion. Mice that undergo BCAS surgery develop the hallmarks of vascular dementia including white matter lesions, neuroinfla