Titlebook: Neurobiological Mechanisms of Opiate Withdrawal; Rafael Maldonado,Luis Stinus,George F. Koob Book 1996 Springer-Verlag Berlin Heidelberg 1

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Book 1996t models currently used to investigate opiate dependence. The neurobiological bases of opiate withdrawal are detailed in a second section, which particularly emphasizes the neurophysiological adaptative changes, the processes of homologous and heterologous regulation, and the role played by differen

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Neuropsychopharmacology of Opiate Dependence,se to repeated administration of the drugs, and persist long after the drug has been cleared from the central nervous system. Two types of mechanisms have been proposed to account for these processes: a within-adaptive system and/or a between-adaptive system..

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Historical Aspects, dysentery epidemics in 1669–1672: “And here I cannot but break out in praise of the great God, the giver of all good things, who hath granted to the human race, as a comfort in their affliction, no medicine of the value of opium, either in regard to the number of diseases it can control, or its efficiency in extirpating them.”.

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