Titlebook: Neuroanatomy and Pathology of Sporadic Alzheimer‘s Disease; Heiko Braak,Kelly Del Tredici Book 2015 The Editor(s) (if applicable) and The

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Basic Organization of Territories That Become Sequentially Involved After Initial Involvement of Brt types of gray matter, i.e., the expansive and, for the most part, uniformly composed neocortex (Fig. 6.1a, yellow, light and deep orange, light and deep blue shading) and a small and heterogeneous allocortex (Fig. 6.1a, red shading). A transition region mediates between the two (Fig. 6.1a, green s

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The Pattern of Cortical Lesions in Preclinical Stages,the cerebral cortex generally in the transentorhinal region. AT8-ir lesions are present in neuronal processes, most probably in terminal portions of axons, and we designate such cases as having “cortical stage 1a” tau pathology (Table .; Figs. 7.1 and 7.2). The predominantly radially aligned thread-

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Early Presymptomatic Stages,aak and Del Tredici 2011; Elobeid et al. 2011; Vana et al. 2011; Trillo et al. 2013). The long and poorly myelinated axons of these nuclei might be capable of reverting to an earlier and less well differentiated state with a higher degree of tau phosphorylation more readily than heavily myelinated axons.

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0301-5556 erimental and molecular-biological aspects of Alzheimer‘s diAs indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in ch

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