Titlebook: Neuro-Beh?et’s Disease; Pathogenesis, Clinic Erdem Tüzün,Murat Kürtüncü Book 2021 Springer Nature Switzerland AG 2021 chronic inflammatory

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Erdem Tüzün,Murat KürtüncüFocuses on Neuro-Beh?et‘s disease.Provides a valuable tool for clinicians, who will need to differentiate Neuro-Beh?et‘s from other inflammatory brain disorders.Offers an overview for basic and clinic

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,Immunology of Neuro-Behcet’s Disease (NBD),s or autoimmune central nervous system disorders. Similarly, autoantibody responses against both local (neurofilament medium) and systemic autoantigens (heat shock proteins, HSPs) are present in the CSF of p-NBD patients; however, whether these responses are pathogenic or just the result of nonspeci

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,Animal Models of Beh?et’s Disease, of BD. The number of animal studies investigating neuro-Beh?et disease (NBD) is very limited. Consequently, it is pertinent to say that further animal models regarding neurological component of BD should be developed to find new biomarkers for NBD and to advance treatment strategies.

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,Beh?et’s Disease: Clinical Features,tis (anterior or panuveitis) and pathergy test, without a pathognomonic biomarker. Male sex and onset at young age (<25?years old) are associated with a more severe disease course and mortality. Beh?et’s disease has a remitting-relapsing course with a decreasing disease activity with older ages.

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,The Cerebrospinal Fluid Presentations of Neuro-Beh?et Disease,and can be easily suppressed by corticosteroid treatment. However, rarely in young MS patients, oligoclonal IgG bands could be absent in the early stages of the disease or can present as a weak single band. Therefore, the presence of oligoclonal bands cannot rule out NBD. CSF IL-6 might be a marker

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,Neuropsychiatric Symptoms in Neuro-Beh?et’s Disease,gnetic resonance imaging (MRI) and single-photon emission computerized tomography (SPECT) studies revealed apparent abnormalities in specific brain regions that were unaffected by the disease process, which may be associated with the occurrence of neuropsychiatric symptoms. Neuropsychological profil

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,Prognosis of Neuro-Beh?et’s Syndrome, at initial presentation, a primary or secondary progressive course, relapse during steroid dose tapering, fever, meningeal signs, bladder involvement, and incomplete recovery are included in poorer prognostic factors. Furthermore, HLA-B51 positivity increases the odds of relapse. Although Beh?et’s

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