Titlebook: Neural Reprogramming; Methods and Protocol Henrik Ahlenius Book 2021 Springer Science+Business Media, LLC, part of Springer Nature 2021 Som

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Direct In Vitro Reprogramming of Astrocytes into Induced Neurons,atal and adult astroglia can be reprogrammed in vitro or in vivo by forced expression of proneural transcription factors, such as Neurogenin-2 or Achaete-scute homolog 1 (Ascl1), to acquire a neuronal fate. The reprogramming process stably induces properties such as distinctly neuronal morphology, e

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Bcl-2-Assisted Reprogramming of Mouse Astrocytes and Human Fibroblasts into Induced Neurons, the efficiency of neuronal conversion is highly dependent on the transcription factor used, the identity of the initial cells to convert, their species’ background, and the neuronal subtype to which cells will convert. Regardless of these conditioning factors, the apoptotic regulator Bcl-2 acts as

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Direct Differentiation of Functional Neurons from Human Pluripotent Stem Cells (hPSCs),etic state of terminally differentiated somatic cells is not static and can be reversed to a more primitive one. Inspired by these results, stem cell biologists have identified approaches to directly convert fibroblasts into induced neuronal (iN) cells, indicating that direct lineage conversions are