Titlebook: Neonatal and Early Onset Diabetes Mellitus; From Pathogenesis to Ivana Rabbone,Dario Iafusco Book 2023 The Editor(s) (if applicable) and Th

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https://doi.org/10.1007/978-3-031-07008-2Diabetes; Diabetes complications; Beta cell disfunction; Non-autoimmune diabetes mellitus; Epilepsy; Perm

Conflict

Rare Forms of Early Onset Diabetes, and treatment that make them unique. All the authors are part of the community of the Italian Study Group on Diabetes of the Italian Society of Paediatric Endocrinology and Diabetology (ISPED) which has always been characterized, for a great collaborative spirit.

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Ivana Rabbone,Dario IafuscoCollects contributions by leading experts on neonatal diabetes.Provides clarification of the pathogenesis of all the forms of diabetes.Covers all aspects of the diagnosis and treatment also discussing

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978-3-031-07010-5The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl

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History of Neonatal Diabetes,aneous recovery. The term neonatal DM now refers to patients up to 1?year of age who present with monogenic DM. It is currently estimated that around 20% of cases still remain without a genetic diagnosis.

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Oral Pharmacological Treatment of Neonatal Diabetes,are definitely less than the benefits..The sulfonylurea of first generation as Glibenclamide exerts its action not only on the beta cell but also on neuromuscular junctions and heart tissue while the more recent Gliclazide acts specifically on insulin secretion only.

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Complications Acute and Chronic,types of neonatal diabetes could present other specific complications related to the characterizing syndrome. In this review, we summarize the most pertinent findings even if very little data are available in the literature.

期滿

Pathogenesis (of Neonatal Diabetes and Early Onset Diabetes),enance of beta cell identity, (b) genes of unfolded protein response/endoplasmic reticulum stress (ER) regulation within the pancreatic beta cell, and (c) genes of metabolic signaling of insulin secretion..In this chapter, we review in some detail the aforementioned mechanisms of disease taking place in NDM and childhood diabetes mellitus (137).