Titlebook: Natural Compounds as Drugs, Volume II; Frank Petersen,René Amstutz Book 2008 Birkh?user Basel 2008 bacteria.cancer.drug.drug discovery.dru

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Chemical-genetic approaches for exploring the mode of action of natural products,mpound function. Moreover, compounds that show similar chemical- genetic profiles often perturb similar target pathways. Gene dosage can be exploited to discover connections between compounds and their targets. For example, haploinsufficiency profiling of an antifungal compound, in which the set of

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,Epothilones as lead structures for new anticancer drugs — pharmacology, fermentation, and structureo B), which are currently at various stages of clinical evaluation in humans. The most advanced of these compounds, Epo B lactam BMS-247550 (ixabepilone), has recently obtained FDA approval for the treatment of metastatic and advanced breast cancer. This chapter will first provide a summary of the b

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Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720,Y720 effectively prevents transplant rejection and is active in various autoimmune disease models. The most striking efficacy is in the multiple sclerosis (MS) model of experimental autoimmune encephalomyelitis, which has now been confirmed in the clinic. FTY720 demonstrated promising results in Pha

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Karl-Heinz Altmann,Klaus Memmert be lessons we can learn from each other’s efforts and each others failures and successes. This book features contributions from experienced researchers who have worked in many different settings and bring their own insights to attack this universal problem..978-90-481-7166-8978-1-4020-4668-1Series ISSN 1573-5397 Series E-ISSN 2214-9791

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Peter C. Hiestand,Martin Rausch,Daniela Piani Meier,Carolyn A. Foster be lessons we can learn from each other’s efforts and each others failures and successes. This book features contributions from experienced researchers who have worked in many different settings and bring their own insights to attack this universal problem..978-90-481-7166-8978-1-4020-4668-1Series ISSN 1573-5397 Series E-ISSN 2214-9791

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Kuhn Thomas,Wang Ying be lessons we can learn from each other’s efforts and each others failures and successes. This book features contributions from experienced researchers who have worked in many different settings and bring their own insights to attack this universal problem..978-90-481-7166-8978-1-4020-4668-1Series ISSN 1573-5397 Series E-ISSN 2214-9791

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be lessons we can learn from each other’s efforts and each others failures and successes. This book features contributions from experienced researchers who have worked in many different settings and bring their own insights to attack this universal problem..978-90-481-7166-8978-1-4020-4668-1Series ISSN 1573-5397 Series E-ISSN 2214-9791

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in transnational theory, the study is based on ethnographic fieldwork in Lydiate, a peri-urban informal settlement of Norton town, a secondary city in Zimbabwe. The study revealed that left alone, marginalised migrants in secondary cities resort to transactions in the form of inheritance, purchase,