Titlebook: Nano-Oncologicals; New Targeting and De Maria José Alonso,Marcos Garcia-Fuentes Book 2014 Controlled Release Society 2014 EPR.RNA delivery.

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The “EX” and the “SOMA”: How They Communicate close or far away target cells is mostly unknown. As we improve our understanding of the biological fate of exosomal-miRNA, we will most likely obtain insights into the mechanisms involved in these events. Exosome mediated drug delivery is a promising strategy to efficiently deliver antitumor miRNA

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Polymeric Nanocarriers for Cancer Therapyseveral types of targeting ligands could be used for active targeting. Furthermore, polymeric nanocarriers have been functionalized to release encapsulated drugs at specific sites or time intervals controlled by environmental triggers, such as pH, temperature, and enzyme. Finally, the application of

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Cancer Immune Modulation and Immunosuppressive Cells: Current and Future Therapeutic Approachescribed, together with other pharmacological and nucleic acid-based strategies, which may take advantage of nanosystems to increase their effectiveness and selectivity. The application of nanotechnology to immunosuppressive and tumor-promoting cell targeting may provide a powerful tool to improve can

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RNAi-Based Nano-Oncologicals: Delivery and Clinical Applicationsuence-defined oligomers can be designed which combine multifunctionality with precision. Functional domains for increased binding of the nucleic acid, receptor targeting and protection of polyplexes against undesired interactions, or enhancing the endosomal escape into the cytosol can be assembled i

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Multifunctional Gold Nanocarriers for Cancer Theranostics: From Bench to Bedside and Back Again?most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, very little gave fruitful results in order to improve a bench-to-bedside approach to translational research. On the bas

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Multimodal Nano-Systems for Cancer Diagnosis, Imaging, and Therapyok chapter focuses on progresses in the nanotechnology-based strategies for diagnosis, imaging, and therapy of cancer with illustrative examples from the recent literature. Such . are designed to evade recognition from host’s immune system, exploit the tumor microenvironment to accumulate at the des