Titlebook: N-Oxidation of Drugs; Biochemistry, pharma P. Hlavica (Full Professor of Pharmacology and Tox Book 1991 Chapman & Hall 1991 Drogen.Oxidatio

Bureaucracy

perimenopause

Human pharmacogenetics of nitrogen oxidationsever their presence has also been demonstrated in other tissues including lung, kidney and intestine. Furthermore, the enzymes of the gut flora are also known to be important mediators of the metabolism of certain xenobiotics.

含水層

F. P. Guengerich,A. Bondon,R. G. B?cker,T. L. Macdonald

發(fā)微光

Factors regulating the activity of the rabbit lung flavin-containing mono-oxygenase al., 1985; Dannan et al, 1986; Tynes and Philpot, 1987). Studies employing gonadectomy of young animals indicate a role for the sex steroids in regulation of FMO (Duffel et al, 1981; Dannan et al, 1986).

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Cervical-Spine

Molecular activation mechanisms involved in arylamine cytotoxicity: peroxidase productsy peroxidases (O’Brien, 1984,O’Brien, 1985,O’Brien, 1988a,O’Brien, 1988b; Meunier, 1987) or the peroxidase activity of prostaglandin H synthase (Boyd and Eling, 1985; Josephy, 1988). Furthermore, suggestive evidence for in vivo peroxidase activation has recently appeared. Thus about 20% of the DNA a

Conquest

Reduction and conjugation reactions of ,-oxidesumulated on nitrogen oxidation (Bridges et al., 1972; Gorrod, 1978; Gorrod and Damani, 1985 and references cited therein), the further metabolism of the .-oxygenated intermediates has not been studied as extensively or systematically. In particular, the reversible nature of certain .-oxygenations un

Foregery

P. Hlavica (Full Professor of Pharmacology and Tox

BROOK

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