| 書目名稱 | mTOR Inhibition for Cancer Therapy: Past, Present and Future | | 編輯 | Monica Mita,Alain Mita,Eric K. Rowinsky | | 視頻video | http://file.papertrans.cn/643/642455/642455.mp4 | | 概述 | First book on that topic.Input and perspectives by international leaders?.Preclinical and clinical data available on the subject have been integrated.A dedicated chapter on toxicity profile of mTOR in | | 圖書封面 |  | | 描述 | .This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs.? .Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compoundscurrently under evaluation. . | | 出版日期 | Book 2016 | | 關(guān)鍵詞 | Akt; cancer; mTOR; rapamycin; Molecular | | 版次 | 1 | | doi | https://doi.org/10.1007/978-2-8178-0492-7 | | isbn_softcover | 978-2-8178-0557-3 | | isbn_ebook | 978-2-8178-0492-7 | | copyright | Springer-Verlag France 2016 |
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