| 書目名稱 | Mycoplasma Infection of Cell Cultures | | 編輯 | Gerard J. McGarrity,Donald G. Murphy,Warren W. Nic | | 視頻video | http://file.papertrans.cn/642/641867/641867.mp4 | | 叢書名稱 | Cellular Senescence and Somatic Cell Genetics | | 圖書封面 |  | | 描述 | If one were to design the ideal nuisance for cell cultures, the resultant might well be similar to mycoplasmas. These micro- organisms are very prevalent in nature, being found in the oral cavity, blood, the mucous membranes of the respiratory and uro- genital tract and other tissues of both man and animals. They are relatively difficult to detect microbiologically and chemically. Lacking cell walls, they do not routinely produce turbidity in cell cultures and are resistant to antibiotics that act on cell walls. Mycoplasmas grow to high titers in cell cultures. Concen- 7 8 trations of 10-10 colony forming units per ml of supernatant medium are representative. Additionally, more numbers are attached to cell membranes. Further, mycoplasmas have been shown to mimic in vitro effects of viruses and toxic chemicals. In various cell culture systems, mycoplasmas have been known to cause cell death, decrease or increase cell growth, affect virus tite~s, induce interferon, cause chromosome damage, induce transformation, cyto- pathic effects, alter phenotypic expression, and significantly alter metabolic pathways and products of cells. The presence of such high concentrations of mycoplasmas i | | 出版日期 | Book 1978 | | 關(guān)鍵詞 | antibiotic; antibiotics; blood; cell; cell culture; cell death; cells; chromosome; death; growth; infection; in | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4684-9874-5 | | isbn_softcover | 978-1-4684-9876-9 | | isbn_ebook | 978-1-4684-9874-5 | | copyright | Springer Science+Business Media New York 1978 |
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