| 書目名稱 | Multifaceted Roles of Crystallography in Modern Drug Discovery | | 編輯 | Giovanna Scapin,Disha Patel,Eddy Arnold | | 視頻video | http://file.papertrans.cn/641/640411/640411.mp4 | | 概述 | Covering a variety of complementary experimental technologies.Providing an up-to-date overview of structure based drug discovery and development.Describing macromolecule-centred and ligand-centred tec | | 叢書名稱 | NATO Science for Peace and Security Series A: Chemistry and Biology | | 圖書封面 |  | | 描述 | .The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bac | | 出版日期 | Conference proceedings 2015 | | 關(guān)鍵詞 | Drug Resistance; Energetics of protein-ligand interactions; GPCR Structures; Structural Basis of Pharma | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-017-9719-1 | | isbn_softcover | 978-94-017-9724-5 | | isbn_ebook | 978-94-017-9719-1Series ISSN 1874-6489 Series E-ISSN 1874-6527 | | issn_series | 1874-6489 | | copyright | Springer Science+Business Media Dordrecht 2015 |
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