| 書(shū)目名稱 | Multi-Drug Resistance in Cancer | | 編輯 | Jun Zhou | | 視頻video | http://file.papertrans.cn/640/639946/639946.mp4 | | 概述 | Collects comprehensive reviews written by leading scientists in the field.Provides up-to-date techniques for detection and imaging of drug transporters.Offers strategies to evaluate the efficacy of re | | 叢書(shū)名稱 | Methods in Molecular Biology | | 圖書(shū)封面 |  | | 描述 | Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in an | | 出版日期 | Book 2010 | | 關(guān)鍵詞 | ATP-binding; Cancer stem cells; Chemotherapy; Drug transporter function; P-glycoproteins; Regulation; Resi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60761-416-6 | | isbn_softcover | 978-1-61779-664-7 | | isbn_ebook | 978-1-60761-416-6Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2010 |
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