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Titlebook: Molecular Basis of Specificity in Nucleic Acid-Drug Interactions; Proceedings of the T Bernard Pullman,Joshua Jortner Conference proceeding

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書目名稱Molecular Basis of Specificity in Nucleic Acid-Drug Interactions
副標(biāo)題Proceedings of the T
編輯Bernard Pullman,Joshua Jortner
視頻videohttp://file.papertrans.cn/639/638044/638044.mp4
叢書名稱Jerusalem Symposia
圖書封面Titlebook: Molecular Basis of Specificity in Nucleic Acid-Drug Interactions; Proceedings of the T Bernard Pullman,Joshua Jortner Conference proceeding
描述One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nu
出版日期Conference proceedings 1990
關(guān)鍵詞biochemistry; chemistry; nucleic acid
版次1
doihttps://doi.org/10.1007/978-94-011-3728-7
isbn_softcover978-94-010-5657-1
isbn_ebook978-94-011-3728-7Series ISSN 0924-4875
issn_series 0924-4875
copyrightSpringer Science+Business Media Dordrecht 1990
The information of publication is updating

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0924-4875 h respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be import
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0924-4875 ation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nu978-94-010-5657-1978-94-011-3728-7Series ISSN 0924-4875
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Molecular Basis of Specificity in Nucleic Acid-Drug InteractionsProceedings of the T
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978-94-010-5657-1Springer Science+Business Media Dordrecht 1990
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Expansion and Lack Thereof in Randomly Perturbed Graphs,s that the graph stops being an expander exactly at the point where a decentralized algorithm is effective in constructing a short path..The proofs of expansion rely on a way of summing over subsets of vertices which allows an argument based on the First Moment Method to succeed.
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