| 書目名稱 | Modern Methods of Drug Discovery | | 編輯 | Alexander Hillisch,Rolf Hilgenfeld | | 視頻video | http://file.papertrans.cn/638/637266/637266.mp4 | | 叢書名稱 | Experientia Supplementum | | 圖書封面 |  | | 描述 | Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov- ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the | | 出版日期 | Book 2003 | | 關(guān)鍵詞 | Proteomics; biochemistry; bioinformatics; biology; chemistry; drug; drug design; drug development; drug disc | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-0348-7997-2 | | isbn_softcover | 978-3-0348-9397-8 | | isbn_ebook | 978-3-0348-7997-2Series ISSN 1664-431X Series E-ISSN 2504-3692 | | issn_series | 1664-431X | | copyright | Springer Basel AG 2003 |
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