| 書目名稱 | Modern Anesthetics | | 編輯 | Jürgen Schüttler,Helmut Schwilden | | 視頻video | http://file.papertrans.cn/637/636913/636913.mp4 | | 概述 | Includes supplementary material: | | 叢書名稱 | Handbook of Experimental Pharmacology | | 圖書封面 |  | | 描述 | Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieve | | 出版日期 | Book 2008 | | 關(guān)鍵詞 | CNS; Modern Anesthetics; anesthesia; depression; drug; kinetics; neurotoxicity; opioid; pain; pharmacodynamic | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-74806-9 | | isbn_softcover | 978-3-642-09192-6 | | isbn_ebook | 978-3-540-74806-9Series ISSN 0171-2004 Series E-ISSN 1865-0325 | | issn_series | 0171-2004 | | copyright | Springer-Verlag Berlin Heidelberg 2008 |
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