Titlebook: Microglia in Health and Disease; Marie-ève Tremblay,Amanda Sierra Book 2014 Springer Science+Business Media New York 2014 aging.microglia.

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Drug Addictiond will be emphasized. Lastly, we will also summarize the development of pharmacological modulators of microglial activation that offer novel treatment strategies and highlight the need to better understand the roles of microglia in the context of drug addiction.

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Agingnal dysfunction observed during normal aging and facilitate the onset of age-associated cognitive decline, as well as neurodegenerative diseases. In this chapter, we describe microglial aging at the cellular and molecular levels, the implications for diseases, and potential strategies to slow down a

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Neurodevelopmental and Neuropsychiatric Disordersion, recent evidence strongly suggests a neurodevelopmental role for microglia in regulating the formation/function of neuronal circuits by their phagocytic activity and structural interactions with synapses. In Rett syndrome (RTT) particularly, microglia become dysfunctional and neurotoxic, thus co

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Prophylaxis

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Amanda Sierra Ph.D.,Marie-ève Tremblay Ph.D.e, and a heretofore unparalleled level of cooperation among investigators, it would be possible to develop a large database of studies to conduct systematic meta-analyses. Such meta-analyses could be of enormous value in identifying common and unique risk and protective factors associated with the w