Titlebook: Microbial Resistance to Drugs; Lawrence E. Bryan (Head) Book 1989 Springer-Verlag Berlin Heidelberg 1989 antibiotic.antibiotics.genetics.m

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Ribosomal Changes Resulting in Antimicrobial Resistance,soluble protein synthesis factors or at the ribosome. The response of susceptible cells to these compounds may be altered by mutational changes of the primary structure of some component of the translational system or by the enzymatic activity of a gene product which introduces a covalent modificati

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Methylation of RNA and Resistance to Antibiotics,olecules may be physically prevented from encountering the target site(s) at which they normally act, either by direct exclusion at membrane barriers or by chemical inactivation due to extracellular enzymes (e.g. .-lactamases). In other instances, where total exclusion of the drug from the cytoplasm

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Resistance to Trimethoprim,ounds possess both antimalarial and antibacterial activity, the former activity exemplified by pyrimethamine and the latter activity by trimethoprim (Tp). Tp is a potent inhibitor of dihydrofolate reductase (5,6,7,8-tetrahydrofolate: NADP. oxidoreductase EC 1.5.1.3; DHFR), an enzyme that catalyzes t

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Clinical Laboratory Testing for Antimicrobial Resistance,cal laboratory are still actively discussed, under development, or undergoing rapid change Browsing in the more than 1000 pages of . in its second edition (. 1986), one feels overwhelmed by the magnitude and complexity of the clinical laboratory aspects of antibiotics and chemotherapeutic agents.

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