Titlebook: Microarray Analysis of the Physical Genome; Methods and Protocol Jonathan R. Pollack Book 2009 Humana Press 2009 BAC.Cancer genomes.Cytosin

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書目名稱Microarray Analysis of the Physical Genome影響因子(影響力)




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Comparative Genomic Hybridization by Representational Oligonucleotide Microarray Analysis, in the phenotype of the cancer cell. The gene expression data are rich in information but the primary lesions responsible for carcinogenesis are obscured due to the complex cascade of expression changes that can occur. The primary lesions can be characterized by the smallest of point mutations to s

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Molecular Inversion Probe Assay for Allelic Quantitation,lications in human genomic and genetic studies include the possibility of running dual germline genotyping and combined copy number variation ascertainment. MIPs analyze large numbers of specific genetic target sequences in parallel, relying on interrogation of a barcode tag, rather than direct hybr

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Algorithms for Calling Gains and Losses in Array CGH Data,ata, including CBS, CLAC, CGHseg, and Fused Lasso. We illustrate the performance of the methods through simulated and real data examples. We also provide brief guidance on how to use the corresponding software at the end of this chapter.

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Methylation Analysis by DNA Immunoprecipitation (MeDIP),nsequent gene silencing is observed for many genes involved in a diverse range of functions and pathways that become deregulated in the disease state. Comparative profiling of the methylome is therefore useful in disease gene discovery. The ability to identify epigenetic alterations on a global scal