Titlebook: MicroRNAs: Key Regulators of Oncogenesis; Sadegh Babashah Book 2014 Springer International Publishing Switzerland 2014 Diagnosis.MicoRNA.O

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MicroRNAs and Regulatory Pathways in Tumorigenesislex signalings in tumorigenesis has led to the development of tumor-specific, molecularly targeted agents against a wide variety of human cancers. Recently, numerous microRNAs (miRNAs) has been identified as having an oncogenic or tumor suppressor property, shown to be involved in cell proliferation

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The Biological Roles of MicroRNAs in Cancer Stem Cellsumors that are associated with poor clinical outcome. Sufficient evidence supports central functions of CSCs in tumorigenesis, due to its distinct high potentials of self-renewal, pluripotent differentiation and apoptosis-resistance, contributing to tumor aggressiveness. Therefore, inhibiting/elimin

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MicroRNAs and Clinical Implications in Cancerundamental roles in development and differentiation, corruption of their expression can lead to the development of disease. In fact, numerous studies have revealed that miRNAs play important regulatory roles in virtually every cancer type studied so far. In this book chapter, I review the current li

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MicroRNA Expression Profiling and Its Clinical Impact in Breast Cancerature of different breast cancer subtypes and to predict outcome and response to therapies. Recently, microRNAs (miRNAs) have been linked to several human diseases, including cancer. An aberrant miRNA expression in breast cancer was first reported in 2005. Now, an increasing body of experimental evi

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MicroRNAs and Their Clinical Impact on Resistance to Anticancer Treatmentblished. In addition, recent studies demonstrated that miRNAs could be used as new therapeutic approach in anticancer treatment including the highly interesting aspect that is regulated by miRNAs: resistance to chemo- and radiotherapy. This chapter aims to elucidate the impact of miRNAs on drug resi

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Challenges and Strategies for Pulmonary Delivery of MicroRNA-Based Therapeuticsterference (RNAi)-based approaches provide a promising modality for the treatment of lung diseases. One of the greatest challenges in RNAi-based therapy continues to be the method for delivering the therapeutic small interfering RNAs (siRNAs) and microRNAs (miRNAs) to the target cells. The advance o

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