Titlebook: MicroRNA Targeted Cancer Therapy; Fazlul H. Sarkar Book 2014 Springer International Publishing Switzerland 2014 Cancer Therapy.Drug Resist

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miRNA Expression and Functions in Glioma and Glioma Stem Cells,Unfortunately, prognosis remains extremely poor and the median survival of 12–14 months in GBM has not changed significantly. GBMs contain a small subpopulation of glioma stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence. Thus, the development of new therapeutic st

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The Role of MicroRNA in Lung Cancer Drug Resistance and Targeted Therapy,motherapeutants to lung cancer cells is the primary issue during the chemotherapy of lung cancer. Many mechanisms such as the changes of drug metabolism related genes and signal pathways are involved in the chemoresistance. MicroRNAs (miRNAs) are a class of endogenetic, non-coding, short-chain and s

Asymptomatic

The Potential Role of MicroRNA-Based Therapy for Lung Cancer Stem Cells, are strongly needed. Increasing evidence indicates that lung cancer stem cells (CSCs) are a therapeutic target for lung cancer. The CSC hypothesis is based on the simple concept that cancers contain a similar hierarchy with respect to self-renewal, differentiation and innate therapy resistance. Inv

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Application of MicroRNA in the Treatment and Diagnosis of Cervical Cancer,berrant miRNA expression is implicated in carcinogenesis and malignancy of cancer. miRNAs involved in carcinogenesis are broadly classified into oncogenic and tumor suppressor miRNAs, and overexpression of oncogenic miRNAs and decreased expression of tumor suppressor miRNAs are found in cancer cells

FAR

Overcoming Drug Resistance in Colorectal Cancer by MicroRNAs,he expression of target genes by cleaving mRNA or through translation repression. As critical gene regulators, microRNAs modulate a variety of cellular events that among others include growth, differentiation and apoptosis. The microRNAs cause cancerous diversity and complexity. Based on microRNA’s

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MicroRNAs as Novel Targets in Liver Cancer: Facing the Clinical Challenge,d by a phenotypic and molecular heterogeneity that limits therapeutic progress. MicroRNAs play a major role for the pathogenesis and progression of liver cancer. As an essential part of the RNA interference machinery, microRNAs contribute to the regulation of many pro-oncogenic processes in HCC, inc

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MicroRNA Based Therapeutic Strategies for Cancer: Emphasis on Advances in Renal Cell Carcinoma,, target prediction, biochemical tools and techniques to modulate miRNA activity, and the emergence of miRNA-centric animal models. One important conclusion that has emerged from this effort is that many microRNAs and their cognate targets are strongly implicated in cancer, either as oncogenes or tu