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Titlebook: Methotrexate; Bruce N. Cronstein,Joseph R. Bertino Book 2000 Springer Basel AG 2000 cancer.diseases.medicine.pathogenesis.psoriasis.resear

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樓主
發(fā)表于 2025-3-21 17:37:13 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Methotrexate
編輯Bruce N. Cronstein,Joseph R. Bertino
視頻videohttp://file.papertrans.cn/633/632441/632441.mp4
叢書名稱Milestones in Drug Therapy
圖書封面Titlebook: Methotrexate;  Bruce N. Cronstein,Joseph R. Bertino Book 2000 Springer Basel AG 2000 cancer.diseases.medicine.pathogenesis.psoriasis.resear
描述Although surprising, it seems fitting that a drug developed at the dawn of the era of rational drug design and therapeutics, methotrexate, should remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medicine is practiced in a number of speciality areas. First developed to treat malignancies, methotrexate is now commonly used to treat gynecological problems, inflammatory arthritis, skin disease and probably other ailments as well. This work is designed to give a broad overview of the history of methotrexate‘s development, its prior use and its current therapeutic uses. As discussed in Chapter I, aminopterin and methotrexate were designed to inhibit mammalian folate metabolism but the concept of folic acid antag- onism was soon applied to the development of antibacterial and anti- parasitic agents. Trimethoprim and sulfa drugs were among the first antibiotics developed and they also remain quite useful today for the treat- ment of a variety of infections.
出版日期Book 2000
關(guān)鍵詞cancer; diseases; medicine; pathogenesis; psoriasis; research; rheumatic diseases; rheumatism
版次1
doihttps://doi.org/10.1007/978-3-0348-8452-5
isbn_softcover978-3-0348-9573-6
isbn_ebook978-3-0348-8452-5Series ISSN 2296-6056 Series E-ISSN 2296-6064
issn_series 2296-6056
copyrightSpringer Basel AG 2000
The information of publication is updating

書目名稱Methotrexate影響因子(影響力)




書目名稱Methotrexate影響因子(影響力)學(xué)科排名




書目名稱Methotrexate網(wǎng)絡(luò)公開度




書目名稱Methotrexate網(wǎng)絡(luò)公開度學(xué)科排名




書目名稱Methotrexate被引頻次




書目名稱Methotrexate被引頻次學(xué)科排名




書目名稱Methotrexate年度引用




書目名稱Methotrexate年度引用學(xué)科排名




書目名稱Methotrexate讀者反饋




書目名稱Methotrexate讀者反饋學(xué)科排名




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沙發(fā)
發(fā)表于 2025-3-21 22:10:32 | 只看該作者
板凳
發(fā)表于 2025-3-22 03:08:22 | 只看該作者
,The mechanisms of methotrexate’s action in the treatment of inflammatory disease,t studies suggest several potential mechanisms of action and new agents developed on the basis of these mechanisms are currently being studied. We will discuss here the biochemical mechanisms by which methotrexate may suppress the inflammation of rheumatoid arthritis.
地板
發(fā)表于 2025-3-22 07:17:34 | 只看該作者
Use of methotrexate in the treatment of psoriasis and other dermatological disorders,common of this group of diseases, estimated to occur in 1-2% of western European populations [.], much of the discussion on the use of MTX in skin disease will be given to MTX and its use in psoriasis.
5#
發(fā)表于 2025-3-22 11:12:19 | 只看該作者
2296-6056 hould remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medicine is practiced in a number of speciality areas. First developed to treat malignancies, methotrexate is now commonly used to treat gynecolog
6#
發(fā)表于 2025-3-22 14:00:21 | 只看該作者
Methotrexate in rheumatoid arthritis,he accepted issues regarding the use of this compound in RA as well as those issues which are less well accepted, but also of concern to the practicing rheumatologist. We will, for the most part, focus on adult patients with RA. The reader is referred to a number of publications dealing exclusively with children with juvenile (J) RA or JRA [.-.].
7#
發(fā)表于 2025-3-22 18:45:02 | 只看該作者
The use of methotrexate in gynecological practice,ies has become widely accepted and practiced in many centers around the world. In addition, methotrexate has been used to treat pregnancies implanted within a uterine scar and in patients with placenta accreta. However, in this chapter we will limit the discussion to the use of methotrexate in the treatment of ectopic pregnancies.
8#
發(fā)表于 2025-3-22 22:39:07 | 只看該作者
Methotrexate, its mechanism of action in malignant disease and mechanisms of resistance by malignan alone or in combination, in the majority of tumors such as acute myelocytic leukemia (AML), intrinsic resistance effectively prevents the use of this agent. In malignancies which are initially sensitive to therapy, e.g. ALL, acquired resistance may develop contributing to treatment failure and relapse [.].
9#
發(fā)表于 2025-3-23 01:33:25 | 只看該作者
ere die Mi- kroprozessoren haben in den letzten Jahren eine stürmische Entwicklung erfahren und viele der Architekturkonzepte, die zun?chst den Gro?rechnern vorbehalten wa- ren, haben in die Architekturen der Mikroprozessoren Eingang gefunden. In anderen Worten, viele der grundlegenden Ideen, welche
10#
發(fā)表于 2025-3-23 09:03:56 | 只看該作者
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