Titlebook: Methods for Preclinical Research in Addiction; María A. Aguilar Book 2022 Springer Science+Business Media, LLC, part of Springer Nature 20

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莎草

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Investigation of Individual Differences in Stress Susceptibility and Drug-Seeking in an Animal Modelstartle response task. Following classification, rats undergo drug-self administration, extinction, and reinstatement. The methods described in this chapter detail a preclinical model of comorbid SUD/PTSD that can be used to identify targets for treatment translatable to the human population.

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0893-2336 ation advice from the experts.This volume presents a wide array of animal models that are used in the study of the individual and environmental factors involved in the development of addiction, the consequences of chronic drug exposure, and recently developed behavioral and biological procedures for

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Animal Models of Adolescent Binge Drinkingn different kinds of memory. The use of these animal models of BD in combination with behavioral tasks will contribute to progress our understanding of the neurobehavioral consequences of BD, as well as to the potential development of prevention and treatment programs.

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Cognitive Biases Associated with Vulnerability to the Development of Pathological Gamblingl feature of gambling-like behavior that has been investigated in rats and humans—the interpretation of “near-miss” outcomes as a positive (i.e., “clear win”) situation..Preclinical modeling of these cognitive distortions in animals can facilitate our understanding of their neurobiological bases and potentially stimulate novel treatment options.

獨(dú)白

Transcranial Direct Current Stimulation to Reduce Addiction-Related Behaviors in MiceS to study its mechanisms of action, using a stimulation protocol similar to those in clinical trials. In this chapter, we will describe this model and its different variants (i.e., tDCS on awake restrained mice; tDCS on anesthetized mice; tDCS in freely moving mice).

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