Titlebook: Methods for Novel Psychoactive Substance Analysis; Marta Concheiro,Karl B. Scheidweiler Book 2023 The Editor(s) (if applicable) and The Au

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Target Analysis of Synthetic Cathinones in Blood and Urine,ecades, they entered in the drug market as substitutes of traditional drugs and made necessary the development of analytical methods for their determination in different biological samples. Blood and urine are the two main biological matrices in clinical and forensic toxicology for testing and evalu

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Target Analysis of Phenethylamines, Tryptamines, and Piperazines in Blood and Urine,tories may be not routinely performed, and it constitutes a challenge due to the high number of substances involved, the constant appearance of novel derivatives in the market, and the low concentrations found in biological samples due to their high potency. In this chapter we summarized the current

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Target Analysis of Designer Benzodiazepines in Blood and Urine, basis. Designer benzodiazepines (DBZD) are sold as “l(fā)egal” substitutes for prescribed benzodiazepines and are one of the most misused pharmaceuticals in the world. Up to 30 DBZD are now being monitored in Europe, 80% of which were detected for the first time between 2014 and 2020. Despite their che

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Target Analysis of NPS in Oral Fluid,cimens investigated for pharmaco-toxicological analyses, oral fluid (OF) provides greater advantages compared to blood to prove drug current use. OF is regarded with particular interest for drug screening at workplace and roadside testing, among others. This chapter contains an overview of analytica

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Target Analysis of NPS in Other Alternative Matrices: Dried Blood Spots and Meconium,es of noninvasive collection procedures. DBS offers an easy storage as well, and meconium is also characterized by a wide window of detection. Most existing studies about the detection of NPS in these two matrices relied on liquid chromatography coupled with tandem mass spectrometry systems (LC-MS/M

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High-Resolution Mass Spectrometry in Identification of New Analytes & Metabolites, new psychoactive substances (NPS) and/or their metabolites for more than a decade. Based on these experiences, current practices in generating, processing, and understanding data are presented in this chapter. Due to the rapidly changing market, searching for NPS should begin before reference mater